Proteins inside the cell face a similar problem. The cell interior is jam-packed with a large number and variety of proteins. Even the simplest bacterium harbors several thousand different types of proteins with numerous copies of each biomolecule existing in the cell’s interior. In many instances, proteins must interact and bind in a highly specific manner with other proteins to carry out their function. These protein-protein interactions (PPIs) are selective. If the wrong proteins bind to each other, the interaction is of no use to the cell.
The jam-packed environment of the cell complicates things. Just like two friends searching for one another in a crowd, proteins are more likely to encounter a protein “stranger” than the desired “friend.”
Biochemists are currently working to understand the specificity of PPIs and how proteins avoid unintended interactions with “strangers.” Recently, Harvard scientists identified some of the key factors that control PPIs.1 Their research adds to the body of evidence that supports the notion that life’s chemistry is designed, stemming from the work of a Creator.
Factors Controlling PPIs
As I wrote previously, protein surfaces are carefully structured to allow strong interactions between protein pairs while minimizing the strength of the unwanted interactions between protein “strangers.” The most recent work by the Harvard scientists indicates that the concentration of PPI-participating proteins in the cell is also carefully designed.
Proteins that do not engage in PPIs have surfaces that prevent these biomolecules from accidently interacting with other proteins. Because of this structural feature, these proteins can exist at relatively high levels inside the cell. Proteins that interact with only one other protein have specific regions on their surfaces designed to promote the PPI. The remainder of the surfaces are designed to eschew PPIs.
Proteins that interact with at least two other proteins also possess specially designed regions that promote binding with their multiple partners. These multi-partner proteins are much more likely to take part in unintended interactions with the wrong partners because more of their surface is devoted to PPIs. To control unwanted interactions, the concentration of these particular proteins is carefully balanced inside the cell.